Scientists reprogram E. coli bacteria to attack tumor cells

August 8, 2016 by  
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Scientists at MIT and the University of California at San Diego (UCSD) have re-engineered E. Coli bacteria to create a helpful super-microbe that attacks tumor cells. Researchers programmed human-safe  E. Coli as bombers in the war against cancer , dropping toxic cocktails in affected areas. When combined with traditional cancer treatment, the altered bacteria shrank aggressive liver tumors in mice far quicker than either treatment separately. “Tumors can be friendly environments for bacteria to grow, and we’re taking advantage of that,” says Sangeeta Bhatia, researcher at MIT and senior co-author of the recent paper that documented these findings. Boosted by a suppressed immune system, bacteria naturally gathers in areas affected by disease. Some bacteria is well adapted to a low-oxygen environment, such as that of a tumor. Harmless E. Coli fits right into this microecosystem and possesses three different mechanisms, provided by artificial genetic circuits, for attacking tumors. One circuit in the altered bacteria creates hemolysin, which damages the cell membranes of tumor cells. Another conjures a drug that tells the tumor cells to self-destruct, while the third delivers a protein which encourages the body’s immune system to attack the tumor. Related: Hacking living cells just got so much easier In addition, the altered E. Coli  possesses a genetic circuit that allows it to sense the nearby population of bacteria through a process called quorum sensing. If the population of helpful  E. Coli  exceeds a certain limit, bacteria are programmed to self-destruct until there is only a small population remaining. “That allows us to maintain the burden of the bacteria in the whole organism at a low level and to keep pumping the drugs only into the tumor,” says Bhatia. The research collaborators are now working to program bacteria to use other weapons against dangerous cells while refining their cancer hunting  E. Coli to suit different forms of cancer. Via MIT News Images via NIAID

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Scientists reprogram E. coli bacteria to attack tumor cells

MAPAs prefab house can be installed and disassembled with minimal environmental harm

August 8, 2016 by  
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The Retreat in Finca Aguy was prefabricated offsite in a factory near Montevideo in a process that minimizes construction waste and saves on costs. The compact structure comprises two identical blocky modules , each measuring around 12.5 meters (41 feet) in length. A truck transported the completed modules 200 kilometers (124 miles) to Pueblo Edén, where they were lowered into place and joined together atop two intersecting stone walls. The architects also installed additional structural elements, hidden from view, to ensure the home’s stability. Related: MAPA Architects’ Tiny MINIMOD House is a LED-Lit Prefab Home for Off-Grid Living Set within an olive grove overlooking beautiful rural views, the house is fortified against the elements with its corrugated metal facade. Full-height glazing is installed into the two long sides of the home but can be shielded from view with movable timber louvers. The interior matches the facade’s material palette, with timber lining the walls, floors, and ceilings, while handsome black furnishings and countertops provide contrast. “In landscapes of high natural value, it is fundamental to respect their original condition and so a reversibility condition is essential,” said the architects to Dezeen . “Prefabrication allows us to work with industrialised materials that enable high-precision processes, thus reducing the impact of construction on the ground, minimising waste, staff in-situ and displacement.” + MAPA Architects Via Dezeen

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MAPAs prefab house can be installed and disassembled with minimal environmental harm

Real life lightsabers? A scientist explains how it might be possible

December 18, 2015 by  
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This week, Don Lincoln, a senior scientist at Fermilab , offered hope to die-hard Star Wars fans everywhere: while we don’t have the technology to create one now, he writes in an article for Space.com , there is some real science behind the lightsaber. And the way it would work isn’t exactly what most movie-goers would expect. Read the rest of Real life lightsabers? A scientist explains how it might be possible

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Real life lightsabers? A scientist explains how it might be possible

Artist converts old truck into book-disseminating ‘Weapon of Mass Instruction’ tank

March 16, 2015 by  
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Read the rest of Artist converts old truck into book-disseminating ‘Weapon of Mass Instruction’ tank Permalink | Add to del.icio.us | digg Post tags: 7up campaign , argentine artist , automotive art , bicycle library , ford focus remodel , free book campaign , library on wheels , library tank , peace mission , Raul Lemesoff , roaming library , Weapons of Mas Instruction tank

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Artist converts old truck into book-disseminating ‘Weapon of Mass Instruction’ tank

Cameron Sinclair Launches the Dead Prize for Designs That Harm Humanity and the Planet

August 7, 2014 by  
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Architects for Humanity co-founder Cameron Sinclair has just launched the Dead Prize , an award “to celebrate engineering, architecture and designs that have had a negative impact on the planet.” Sinclair believes that there are plenty of prizes celebrating good design , but nothing that acknowledges when something has miserably failed its end users or the environment. The prize is intended to become an annual event, with submissions closing on 1 November each year. Read on to see how you can nominate the design you think is most (or is that least?) worthy. Read the rest of Cameron Sinclair Launches the Dead Prize for Designs That Harm Humanity and the Planet Permalink | Add to del.icio.us | digg Post tags: Architects for Humanity , Architecture , awards , bad design , cameron sinclair , environmentally harmful design , industrial design , nominations , prizes , The Dead Prize , urban planning , weapons

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Cameron Sinclair Launches the Dead Prize for Designs That Harm Humanity and the Planet

Scientists Criticize Plans to Destroy Syrian Chemical Weapons at Sea

February 11, 2014 by  
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The UN has confirmed that a shipment of chemical weapons has left Syria, and is on route to be destroyed by the US Navy in a first-of-its-kind mission at sea. While the United States has plenty of experience destroying chemical weapons on land, no one has ever attempted to neutralize such weapons on a seagoing vessel. The planned operation will take place in international waters on the MV Cape Ray , because no individual country has been willing to risk the dangerous materials being released on their soil. Read the rest of Scientists Criticize Plans to Destroy Syrian Chemical Weapons at Sea Permalink | Add to del.icio.us | digg Post tags: Cioia Tauro , decommissioning chemicals weapons , hydrolysis system , italy , mustard gas , mv cape ray , OPCW , Organization for the Prohibition of Chemical Weapons , sarin gas , Syria , syrian chemical weapons , United Nations        

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Scientists Criticize Plans to Destroy Syrian Chemical Weapons at Sea

Goncalo Mabunda Upcycles Weapons of the Mozambique Civil War into Beautiful Furniture

July 8, 2013 by  
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Mozambican designer Gonçalo Mabunda’s gorgeous sculptural chairs, furniture and masks are made from upcycled guns . The artist transforms symbols of his country’s civil war-torn past, including AK-47s, rocket launchers, pistols and other weapons, into beautiful pieces of art. The furniture and chairs will be displayed in a new exhibition at the Jack Bell Gallery next week. Read the rest of Goncalo Mabunda Upcycles Weapons of the Mozambique Civil War into Beautiful Furniture Permalink | Add to del.icio.us | digg Post tags: eco design , Goncalo Mabunda , green design , Jack Bell Gallery , mozambique , recycled guns , sustainable design , upcycled guns        

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Goncalo Mabunda Upcycles Weapons of the Mozambique Civil War into Beautiful Furniture

President Obama Issues Executive Order to Protect Africa’s Elephants and Rhinos

July 8, 2013 by  
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Image via Shutterstock Illegal wildlife trafficking imperils the continued existence of Africa’s elephants and rhinos, and it poses an increasingly dangerous security threat. During his recent tour of Africa, President Obama promised to help countries like Tanzania curtail the threat, and he has issued an executive order to do so. Read the rest of President Obama Issues Executive Order to Protect Africa’s Elephants and Rhinos Permalink | Add to del.icio.us | digg Post tags: Africa tour , Elephant , extinction , illegal wildlife trade , ivory , president obama , presidential executive order , presidential task force , rhino , security threat posed by wildlife trafficking , tanzania , wildlife trafficking        

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President Obama Issues Executive Order to Protect Africa’s Elephants and Rhinos

Pedro Reyes Creates an Orchestra of Mechanical Instruments from Upcycled Mexican Weapons

July 3, 2013 by  
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Read the rest of Pedro Reyes Creates an Orchestra of Mechanical Instruments from Upcycled Mexican Weapons Permalink | Add to del.icio.us | digg Post tags: Cocolab , Disarm , eco design , green design , gun instruments , pedro reyes , recycled guns , recycled weapons , sustainable design        

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Pedro Reyes Creates an Orchestra of Mechanical Instruments from Upcycled Mexican Weapons

Sonia Rentsch Creates Harmless Weapons from Organic Materials

May 13, 2013 by  
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Read the rest of Sonia Rentsch Creates Harmless Weapons from Organic Materials Permalink | Add to del.icio.us | digg Post tags: albert comper , australia , christian dior , firearm , january biannual , loreal , Nature , organic material , RMIT University , sonia rentsch , violence , weapons        

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Sonia Rentsch Creates Harmless Weapons from Organic Materials

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